biology

David Sinclair is either the most important longevity researcher of our time or a very effective salesman of supplements. Possibly both. The Harvard geneticist has built his career around a simple claim: aging is not an inevitable decay but an information problem that can be addressed. The central mechanism, in

Series: Longevity Science | Part: 3 of 7 Primary Tag: FRONTIER SCIENCE Keywords: senolytics, senescent cells, SASP, dasatinib, quercetin, aging, fisetin In 2011, researchers at Mayo Clinic did something remarkable. They engineered mice with a genetic kill switch—a system that let them selectively destroy one type of cell throughout the

Series: Longevity Science | Part: 7 of 7 Primary Tag: FRONTIER SCIENCE Keywords: healthspan, lifespan, longevity, aging, quality of life, compression of morbidity Here's a question that doesn't get asked enough in longevity science: Why do we want to live longer? The obvious answer—more time—isn&

Series: Longevity Science | Part: 6 of 7 Primary Tag: FRONTIER SCIENCE Keywords: Altos Labs, Calico, longevity companies, Jeff Bezos, Google, anti-aging, biotech In January 2022, a new biotech company launched with $3 billion in funding—the largest initial funding in biotech history. It recruited Nobel laureates, poached top researchers from

Series: Longevity Science | Part: 4 of 7 Primary Tag: FRONTIER SCIENCE Keywords: telomeres, Hayflick limit, telomerase, Elizabeth Blackburn, cellular aging, replicative senescence In 1961, Leonard Hayflick made a discovery that nobody wanted to believe. He was trying to grow human cells in culture, and they kept dying. This shouldn'

In 2012, a six-year-old girl named Emily Whitehead was dying of leukemia. She had relapsed twice after chemotherapy. There were no more standard options. Her doctors at the Children's Hospital of Philadelphia tried something that had never worked before: they extracted her T cells, genetically modified them to