ideasthesia

Sign in Subscribe

science

Token-space geometry, organoid intelligence, constructor theory, active inference frontiers — where silicon and biology begin to share the same manifold. Explore the lattice → [M=T/C](/tag/m-t-c/) • [Theory](/tag/atom-theory/) • [Neurodiversity](/tag/neurodiversity/)

Trained Immunity: Memory Without Memory Cells

Trained Immunity: Memory Without Memory Cells

Series: New Immunology | Part: 3 of 8 Primary Tag: FRONTIER SCIENCE Keywords: trained immunity, BCG vaccine, innate immune memory, epigenetics, monocytes, macrophages For decades, immunology had a clean division: innate immunity is fast but doesn't learn; adaptive immunity is slow but remembers. The textbooks were clear. The T

Checkpoint Inhibitors: Releasing the Brakes on Cancer

Checkpoint Inhibitors: Releasing the Brakes on Cancer

Series: New Immunology | Part: 4 of 8 Primary Tag: FRONTIER SCIENCE Keywords: checkpoint inhibitors, PD-1, CTLA-4, cancer immunotherapy, James Allison, Tasuku Honjo, Nobel Prize In the 1990s, two researchers—working independently, on different continents—discovered something that would transform cancer treatment. Their discoveries weren't about killing cancer cells

The Bioelectric Code

The Bioelectric Code

Your Body Runs on Electricity—And It Matters More Than You Think Here's something you probably didn't learn in biology class: every cell in your body maintains an electrical voltage across its membrane. Not just neurons—every cell. Your skin cells, your liver cells, your stem

The Language of Immunity: A Synthesis

The Language of Immunity: A Synthesis

Series: New Immunology | Part: 8 of 8 Primary Tag: FRONTIER SCIENCE Keywords: immunology, systems biology, information processing, coherence, self-recognition We've traveled through the immune system: from the ancient innate responses to the learning adaptive system, from trained immunity to cancer immunotherapy, from the gut-immune axis to neuroinflammation. The

Long COVID and Cytokine Storms: When the Immune System Won't Stand Down

Long COVID and Cytokine Storms: When the Immune System Won't Stand Down

Here's a puzzle that emerged from the pandemic: why do some people recover from COVID-19 in days, while others—even those with mild initial infections—develop symptoms that last for months or years? The answer appears to be immune dysregulation. Not infection persisting, but the immune response itself

When the Immune System Attacks Itself: Autoimmunity and the Failure of Tolerance

When the Immune System Attacks Itself: Autoimmunity and the Failure of Tolerance

Series: New Immunology | Part: 6 of 8 Primary Tag: FRONTIER SCIENCE Keywords: autoimmunity, tolerance, rheumatoid arthritis, multiple sclerosis, lupus, regulatory T cells The immune system's fundamental job is discrimination: self versus non-self, dangerous versus harmless. Get it right, and you're protected from infections while leaving your

Planarian Regeneration: The Champion Regenerators

Planarian Regeneration: The Champion Regenerators

Series: Bioelectric Code | Part: 5 of 7 Primary Tag: FRONTIER SCIENCE Keywords: planaria, regeneration, stem cells, bioelectric memory, morphogenesis, Michael Levin Cut a planarian flatworm in half. Each half regenerates into a complete worm. Cut it into twenty pieces. You get twenty complete worms. Cut off its head. It grows