science

When old mice share circulation with young mice, the old mice get measurably younger — better muscle function, sharper cognition, reduced inflammation. The experiments are reproducible; identifying the active factors has been far messier, and clinical hype has run well ahead of the science.

Shinya Yamanaka won the Nobel Prize for reprogramming adult cells into stem cells. Now researchers want something more precise: dial the clock back on aging without wiping out what makes a cell a liver cell or a neuron.

Harvard's David Sinclair takes NMN every morning based on his theory that aging is a loss of epigenetic information, not irreversible damage. NAD+ and sirtuin proteins are central to his framework — and to a fierce scientific debate.

Senescent cells are biological zombies: they've stopped dividing but linger in tissues, leaking inflammatory signals that damage neighboring cells. Senolytic drugs can selectively clear them — and in mice, the results are striking.

The goal was never just more years — it was more good years. Healthspan science identifies the cellular and molecular processes behind decline, and increasingly has interventions that move the needle on both.

The Longevity Gold Rush: Billionaires Betting on Reversing Aging Series: Longevity Science | Part: 6 of 7 Primary Tag: FRONTIER SCIENCE Keywords: Altos Labs, Calico, longevity companies, Jeff Bezos, Google, anti-aging, biotech Why Now? Longevity research has existed for decades. Why did it suddenly become attractive to billionaires? Scientific momentum: The