science

Parabiosis: Young Blood and Old Bodies In 1864, French physiologist Paul Bert stitched two rats together. Not metaphorically. He surgically joined them so they shared a circulatory system—blood flowing from one animal into the other and back. He called it parabiosis, from the Greek for "living beside."

Yamanaka Factors: Reversing Cellular Age In 2006, Shinya Yamanaka did something that shouldn't have been possible. He took adult mouse skin cells—fully differentiated, committed to their fate—and turned them back into embryonic-like stem cells. Four genes. That's all it took. Four transcription factors, now

NAD+ and Sirtuins: David Sinclair's Protocol David Sinclair is either the most important longevity researcher of our time or a very effective salesman of supplements. Possibly both. The Harvard geneticist has built his career around a simple claim: aging is not an inevitable decay but an information problem

Zombie Cells and the Drugs That Kill Them Series: Longevity Science | Part: 3 of 7 Primary Tag: FRONTIER SCIENCE Keywords: senolytics, senescent cells, SASP, dasatinib, quercetin, aging, fisetin What Senescent Cells Are Senescent cells are cells that have permanently exited the cell cycle. They can't divide anymore. But

Lifespan vs. Healthspan: A Synthesis Series: Longevity Science | Part: 7 of 7 Primary Tag: FRONTIER SCIENCE Keywords: healthspan, lifespan, longevity, aging, quality of life, compression of morbidity The Morbidity Rectangle In 1980, James Fries at Stanford proposed an optimistic vision: compression of morbidity. The idea was simple. If we could

The Longevity Gold Rush: Billionaires Betting on Reversing Aging Series: Longevity Science | Part: 6 of 7 Primary Tag: FRONTIER SCIENCE Keywords: Altos Labs, Calico, longevity companies, Jeff Bezos, Google, anti-aging, biotech Why Now? Longevity research has existed for decades. Why did it suddenly become attractive to billionaires? Scientific momentum: The