biology

NAD+ and Sirtuins: David Sinclair's Protocol David Sinclair is either the most important longevity researcher of our time or a very effective salesman of supplements. Possibly both. The Harvard geneticist has built his career around a simple claim: aging is not an inevitable decay but an information problem

Zombie Cells and the Drugs That Kill Them Series: Longevity Science | Part: 3 of 7 Primary Tag: FRONTIER SCIENCE Keywords: senolytics, senescent cells, SASP, dasatinib, quercetin, aging, fisetin What Senescent Cells Are Senescent cells are cells that have permanently exited the cell cycle. They can't divide anymore. But

Lifespan vs. Healthspan: A Synthesis Series: Longevity Science | Part: 7 of 7 Primary Tag: FRONTIER SCIENCE Keywords: healthspan, lifespan, longevity, aging, quality of life, compression of morbidity The Morbidity Rectangle In 1980, James Fries at Stanford proposed an optimistic vision: compression of morbidity. The idea was simple. If we could

The Longevity Gold Rush: Billionaires Betting on Reversing Aging Series: Longevity Science | Part: 6 of 7 Primary Tag: FRONTIER SCIENCE Keywords: Altos Labs, Calico, longevity companies, Jeff Bezos, Google, anti-aging, biotech Why Now? Longevity research has existed for decades. Why did it suddenly become attractive to billionaires? Scientific momentum: The

Telomeres and the Hayflick Limit: Your Cells Can Only Divide So Many Times Series: Longevity Science | Part: 4 of 7 Primary Tag: FRONTIER SCIENCE Keywords: telomeres, Hayflick limit, telomerase, Elizabeth Blackburn, cellular aging, replicative senescence The End Replication Problem To understand telomeres, you need to understand a fundamental problem with

CAR-T Therapy: Engineering Cancer Killers In 2012, a six-year-old girl named Emily Whitehead was dying of leukemia. She had relapsed twice after chemotherapy. There were no more standard options. Her doctors at the Children's Hospital of Philadelphia tried something that had never worked before: they extracted her T