Organoid Intelligence

Organoid Intelligence
Wetware computing: when neurons in dishes learn faster than silicon.

Organoid Intelligence

What if the most powerful computer you could build wasn't made of silicon, but of neurons?

Brain organoids—miniature self-organizing neural tissue grown from stem cells—are already being trained to play Pong, control robots, and recognize patterns. They're not conscious (probably), but they are computational. And they're orders of magnitude more energy-efficient than any artificial neural network we've built.

This isn't science fiction. It's the emerging field of organoid intelligence: using biological neural tissue as a computational substrate. The hardware of the future might not be chips at all. It might be wetware.

Why This Matters for Coherence

Biological systems achieve coherent computation through mechanisms we still barely understand. Growing neural tissue and teaching it to compute gives us unprecedented access to how coherence maintenance actually works in biological substrates—how networks learn, self-organize, maintain stability, and generalize.

Organoid intelligence isn't just about building better computers. It's about understanding what coherence looks like when implemented in the same substrate that gave rise to minds in the first place.

Articles in This Series

Brains in a Dish: The Promise and Peril of Organoid Intelligence
Introduction to organoid intelligence—why brain tissue might outcompute silicon by orders of magnitude.
How to Grow a Brain: The Science of Cerebral Organoids
The biology of brain organoid development—from stem cells to structured neural tissue.
The Energy Equation: Why Wetware Beats Silicon
Quantifying the efficiency advantage of biological computation—why organoids could be 10^6 more efficient than GPUs.
Teaching Organoids: How Brain Tissue Learns
Training paradigms for organoid intelligence—how biological networks acquire and store information.
The Interface Problem: Connecting Wetware to Hardware
Brain-computer interfaces for organoid systems—the engineering challenge of reading and writing to neural tissue.
DishBrain and Beyond: Current State of the Field
Survey of actual organoid intelligence research—Cortical Labs and other pioneers.
The Ethics of Organoid Intelligence: When Does Tissue Become Someone?
Ethical frameworks for organoid research—consciousness, moral status, and responsible development.
Organoids Meet Active Inference: Biological Free Energy Minimizers
How organoid systems might naturally implement active inference—wetware as FEP hardware.
Synthesis: What Organoid Intelligence Teaches About Biological Coherence
Integration showing how organoid research illuminates the relationship between biological substrate and coherent cognition.